Lepage was born in Paris, France in 1960. He was first introduced to photography by his uncle who was art director at Cosmopolitan magazine. He then discovers the work of the street photographers Henri Cartier Bresson, William Eugene Smith and Robert Frank as well as the fashion photographers Erwin Blumenfeld, Helmut Newton and Guy Bourdin. In 1977, Jean-François Lepage left school before graduating and worked at the post office. Two years later, after a one-year trip to the United States and Mexico, Lepage joined the photographer's assistant team of the Marie-Claire magazine studio in Paris. He started his photographic career in 1980 and made his first exhibition of portraits of the French actress isabelle Adjani in 1983. His early photographs featured in magazines such as Depeche Mode, Jill Magazine, Vogue UK and Condé Nast Publications in Italy. After the birth of his son Vincent, Jean-François Lepage began to devote himself to drawing and painting in 1987. During his self-imposed exile from editorial photography, Lepage has shot the album cover of the German singer Nina Hagen in 1989 (''Nina Hagen)'' as well as campaigns for Laura Urbinati in 1988, Jil Sander in 1990 and Masaki Matsushima in 1998.
Lepage returned with a new approach in 2001 – moving outside the studio to create new series of stories for magazines. In this work Lepage intentionally showed the source used to light his subjects and to compose and balance his flash light with the Sun, to create a new perspective. Over the past three decades, his photographs were published in international magazines such as Another Man Magazine, Double, Exit (magazine), Italian Amica, Purple (magazine) and Vogue among many others. His work at the intersection of painting, cinema and contemporary photography, represents a very different way of seeing the world of fashion. His approach is similar to that of the Plastic arts and illustrates a significant change in fashion photography.〔TIME LightBox – ''(These Experimental Fashion Photographs Push Boundaries ) by Phil Bicker''〕 In 2013, Lepage worked with curator Raphaëlle Stopin to present the exhibition ''Memories from the Future'' during the 28th International Hyères Festival of Fashion and Photography.
In 2014, Jean-François Lepage has begun to pull away from fashion. MOONLIGHT ZOO, his first monograph was published in April 2015 by Prestel Publishing while at the same time his latest series entitled ''Recycle (prelude)'' ''–'' the first opus of his most recent photographic work ''–'' was exhibited in Paris, Amsterdam and London.〔(Recycle: Reimagining Fashion ) ''–'' LensCulture〕